Abstract
At the early stage of trypsin treatment of mollusc neurones tetrodotoxin cannot block the Na + current. In the course of further exposure of neurones to trypsin, tetrodotoxin-sensitivity is restored completely, so its temporal loss results from shielding rather than destruction of the tetrodotoxin-binding site. Pronase and papain do not affect the tetrodotoxin action on the Na + current.
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