Abstract
Host responses to infection were examined by observing the ultrastructural changes in liver from rats infected withTrypanosoma lewisi from day 1 to day 49 of infection. Trypanosomes were present in large numbers in the sinusoids on the 7th day of infection. By day 14, trypanosomes were seen in kupffer cells. The endoplasmic reticulum showed distended cisternae from day 4 of infection to day 14 of infection. Mitochondria in liver from infected rats increased in number and were swollen only on day 7 of infection. The hepatocytes showed focal areas of lipid from day 7 to day 28 of infection. Residual lysosomes in kupffer cells were found from the 14th to 21st day of infection. Initially, glycogen was dispersed but as the infection advanced, it became aggregated by day 7 of infection. By the 49th day of infection, glycogen again appeared dispersed. At the 35th, 42nd and 49th days of infection, the appearance of the liver was similar in general to that of normal liver.
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