Abstract

Dr. Carlos Chagas, in 1909, published his notable discovery, a new pathology denominated Chagas disease. He was able to identify: etiologic agent, the protozoan Trypanosoma cruzi, its biological cycle and your pathogenesis: etiologic agent, the protozoan T. cruzi its biological cycle and your pathogenesis. However, to date, there is still no vaccine or effective treatment for the symptomatic chronic phase. In 2019, a new Severe Acute Respiratory Syndrome, promoted by a member of the Coronavirus family, emerged in Wuhan (China province), whose origin has not yet been totally elucidate. SARS-Cov-2 or COVID-19 is characterize by high transmissibility and high morbidity. Thus, in 2020 it became a global pandemic. Highlights into similarities between a neglected disease, which affects 40.000 new cases per year and intense research for a vaccine and treatment using experimental models and severe COVID-19 infection, with millions of victims, by evolution to cardiovascular disturbance, mainly through its target point to ACE2 enzyme. To compare acute T. cruzi experimental infection in mice, the cardiorenal axis involvement and suggest possible common points to research about serious course of the COVID- 19 infection and cardiovascular involvement.

Highlights

  • IntroductionTrypanosoma Infection: Dr Carlos Chagas, in 1909, published his notable discovery, a new pathology denominated Chagas disease [1]

  • Trypanosoma Infection: Dr Carlos Chagas, in 1909, published his notable discovery, a new pathology denominated Chagas disease [1]. He was able to identify: etiologic agent, the protozoan Trypanosoma cruzi, its biological cycle and your pathogenesis [2]. This disease affects a large part of the world population in a situation of social vulnerability, considered a neglected disease (NTDs) [3]

  • In vitro, the several types infection of renal cells infected by T. cruzi and observed that there was an inverse relationship, mainly in mesangial cells, that the presence of the parasite, not necessarily replicating in renal tissue, increased the oxide nitric levels in the cell culture supernatant, as well as cytokine TNF [30]

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Summary

Introduction

Trypanosoma Infection: Dr Carlos Chagas, in 1909, published his notable discovery, a new pathology denominated Chagas disease [1]. With the refinement of techniques and the use of transgenic models using the mouse model, it became possible, especially in Outbred Stock mice, to evaluate, in a short period of time, the evolution of the acute phase, the symptoms in the chronic phase and the effectiveness of experimental compounds, more closely the possibility of translating the results to the patient with reliability [17]. Experimental murine infection, in the acute and chronic phase, has always had a primary focus on cardiac involvement and the, still unknown, mechanism to which asymptomatic patients develop Chagas’ heart disease [27]. Among striking differences, the use of the mouse biomodel in both infections is not contemplating the elements of the complex network associated between the various biological systems, such as only the cardiac involvement in T. cruzi infection and the involvement of the lung in the case of COVID-19. Al. [16] the severity criteria for COVID-19 infection are determined by

Severe Respiratory: severe hypoxemia
Findings
Conclusions

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