Abstract
The trypanocidal, toxicity and haematological effect of ethanolic root extract of Mitragyna ciliata Aubrev and Pellerg (Rubiaceae) was evaluated in T. brucei brucei infected rats. Fractions of the extract were administered at 50mg/kg to T.b. brucei infected rats 7 days after infection for 5 days. The butanol fraction had the highest trypanocidal activity with inhibition of parasites' growth of 68.68% compared diaceturate (100%). Administration of 800mg/kg dose of the extract for 30 days caused decrease (p<<0.05) in PCV, ALP, ALT, AST, and creatinine, while there was elevation (p<0.05) in bilirubin. There was a decrease (p<0.05) in PCV, WBC and platelets count in all infected rats compared to uninfected when different fractions of the extract were administrated. Results suggest that trypanocidal activity of M. ciliata resides in the butanol fraction and it has a hepatobilliary effect of M.ciliata. Data was consistent with characteristics of trypanosomiasis – anaemia [1], leucocytopaenia and thrombocytopaenia [2].
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