Trypanocidal function of Terminalia catappa leaf extract in Albino rat

Deborah Adebukola Oloruntola

doi:10.15414/afz.2021.24.04.326-333

Abstract

Trypanocidal function of Terminalia catappa leaf extract in Albino rat

Highlights

Trypanosomiasis is an infection caused by a parasite in both man and animals
The effect of Terminalia catappa ethanolic extract on the Parasitemia level/day (×103 μ ml-1) of albino rats infected with Trypanosoma brucei brucei EETL – ethanolic extract of Terminalia catappa leaf; Group 1: control; Group 2: infected; Group 3: infected and medicated with 10 mg kg-1 body weight diminazene aceturate; Group 4:infected and medicated with 500 mg kg-1 body weight EETL; Group 5: infected and medicated with 1,000 mg kg-1 body weight EETL; Group 6: infected and medicated with 1,500 mg kg-1 body weight EETL
The effect of Terminalia catappa ethanolic extract on the white blood cell count of albino rats infected with Trypanosoma brucei brucei EETL – ethanolic extract of Terminalia catappa leaf; Group 1: control; Group 2: infected; Group 3: infected and medicated with 10 mg kg-1 body weight diminazene aceturate; Group 4:infected and medicated with 500 mg kg-1 body weight EETL; Group 5: infected and medicated with 1,000 mg kg-1 body weight EETL; Group 6: infected and medicated with 1,500 mg kg-1 body weight EETL

Summary

Introduction

Trypanosomiasis is an infection caused by a parasite in both man and animals. The disorder is brought about by the Trypanosoma parasite, a protozoan parasite belonging to the Trypanosoma genus. The trypanosomes, the aetiology of animal trypanosomiasis and human African trypanosomiasis (HAT) are spread by the Glossina spp. Trypanosomaisis is common in areas of Sub-Saharan Africa where the climate and atmosphere are ideal for the tse ste fly, which covers an area of up to 8.7 million square kilometers (Baker et al, 2013). The presence of trypanosome in the encephalon can bring about neuronal disintegration, resulting in a coma or death if adequate care is not provided (WHO, 2013). Rhodesiense is responsible for HAT, while T. brucei spp, T. vivax, and T. congolense is the foremost popular pathogenic trypanosome causing the animal trypanosomiasis (Giordani et al, 2016) The T. b. gambiense or T. b. rhodesiense is responsible for HAT, while T. brucei spp, T. vivax, and T. congolense is the foremost popular pathogenic trypanosome causing the animal trypanosomiasis (Giordani et al, 2016)

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Conclusion