Trypan Blue and Growth of the Adrenal Cortex in Mice

Abstract

ACCORDING to a recent communication, Calma and Foster1 have been unable to demonstrate centripetal cell migration in the adrenal gland of the rat by the use of trypan blue. Salmon and Zwemer2, using the same vital stain, had previously reported inward cell movement. These last-mentioned workers injected the dye subcutaneously and found it taken up first by the cells in the capsule and after varying intervals by cells of the glomerulosa, fasciculata, and reticulosa successively, while the outer layers became dye-free.