Abstract
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for elimination as a public health problem by 2020 and 0 transmission by 2030 [1,2]. Control of g-HAT is largely based on identification and treatment of infected individuals, supplemented by control of the tsetse fly vectors [3]. There has been growing evidence that when both tsetse control and case identification activities are carried out simultaneously in the same geographies, elimination of the disease is accelerated [4–6]. Here, we describe how the Trypa-NO! Partnership is using novel and classical tools to drive g-HAT elimination in an integrated approach, progress made, lessons learnt, and future directions.
Highlights
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for elimination as a public health problem by 2020 and 0 transmission by 2030 [1,2]
The Central Information Repository (CIR) is a database that consolidates in 1 location, data, and materials that are of relevance for analysing and understanding programme activities, evaluating progress towards the Partnership’s goals, and guiding implementation of activities, as illustrated in S2 Fig. Data on vector control and medical activities included in the CIR are cleaned and enriched by addition of geo-coordinates if the data are not already georeferenced, and through data sharing agreements (DSAs), made available to anyone that may be interested in using it, such as modellers
The number of g-HAT cases reported annually in Cote d’Ivoire and Uganda is close to 0, with an impressive reduction in the number reported in Guinea (50% reduction from 2017) and in Chad (68.5% reduction from 2016), increasing the prospects of reaching the goal of 90% reduction by 2022
Summary
Vestergaard SA is currently donating all the Tiny. Hassane Mahamat Hassane, Inaki Tirados, Isabel SaldanhaID6, Jacques Kabore, JeanBaptiste Rayaisse2‡, Jean-Mathieu BartID8, Jessica Lingley, Johan Esterhuizen, Joshua Longbottom, Justin PulfordID6, Lingue Kouakou, Lassina Sanogo, Lucas Cunningham, Mamadou Camara, Mathurin KoffiID14, Michelle Stanton, Mike LehaneID6, Moise Saa Kagbadouno, Oumou Camara, Paul BessellID15, Peka Mallaye, Philippe SolanoID8, Richard SelbyID6, Sophie DunkleyID6, Steve Torr, Sylvain BielerID1, Veerle LejonID8, Vincent Jamonneau, Wilfried Yoni, Zachary KatzID1
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