Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation

Abstract

ObjectiveEndogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism. MethodsThree hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16–58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance® ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters. ResultsIn the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP. ConclusionTrunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.