Abstract
The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers. TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis. In leukemia and bladder cancer, the oncogenic activity of TRPV2 was linked to alteration of its expression profile. In multiple myeloma patients, TRPV2 overexpression correlated with bone tissue damage and poor prognosis. In prostate cancer, TRPV2 overexpression was associated with the castration-resistant phenotype and metastasis. Loss or inactivation of TRPV2 promoted glioblastoma cell proliferation and increased resistance to CD95-induced apoptotic cell death. TRPV2 overexpression was associated with high relapse-free survival in triple-negative breast cancer, whereas the opposite was found in patients with esophageal squamous cell carcinoma or gastric cancer. Another link was found between TRPV2 expression and either drug-induced cytotoxicity or stemness of liver cancer. Overall, these findings validate TRPV2 as a prime candidate for cancer biomarker and future therapeutic target.
Highlights
Cancer patients could get a significant clinical benefit from the identification of molecular targets that play a polar role in tumor cell growth and survival, amenable to an approach with preciseness in patient medication
This review focuses on the pathophysiological significance of the TRPV2 channel in many kinds of cancers, and we hope to offer the reader a flavor of how the measurable molecular changes in TRPV2 could validate its quality as a cancer biomarker and potential therapeutic target
This study showed that targeting TRPV2 could affect the signaling pathways associated with chemotaxis/infiltration processes, prompting the assessment of TRPV2 as a potential pharmacodynamic biomarker especially in the setting where leukemia might be associated with a high risk of organ infiltration by leukemic blasts (LBs)
Summary
Cancer patients could get a significant clinical benefit from the identification of molecular targets that play a polar role in tumor cell growth and survival, amenable to an approach with preciseness in patient medication. The concept of precision medicine, which consists of identifying the molecular signature of individual tumors that can be selected for the most appropriate therapeutic approach, has become the pivot of contemporary oncology. On this basis, for biomarkers to assume their rightful role, they need to be befittingly altered by effective therapeutic interventions and modify the definition of the populations of patients who presumably will benefit from precision medicine. This review focuses on the pathophysiological significance of the TRPV2 channel in many kinds of cancers, and we hope to offer the reader a flavor of how the measurable molecular changes in TRPV2 could validate its quality as a cancer biomarker and potential therapeutic target
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