Abstract
BackgroundMany single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We aimed to investigate the associations of pre-identified migraine susceptibility loci in Taiwanese with migraine endophenotypes or subtypes, including chronic migraine and allodynia.MethodsThe associations of six SNPs identified from our previous study, including TRPM8 rs10166942, LRP1 rs1172113, DLG2 rs655484, GFRA1 rs3781545, UPP2 rs7565931, and GPR39 rs10803531, and migraine endophenotypes, including chronic migraine and allodynia were tested. Significant associations in the discovery cohort were validated in the replication cohort. The adjusted odds ratios (aOR) were calculated after controlling for confounders.ResultsIn total, 1904 patients (mean age 37.5 ± 12.2 years old, female ratio: 77.7%) including 1077 in the discovery cohort and 827 in the replication cohort were recruited. Of them, 584 (30.7%) had chronic migraine. Of the 6 investigated SNPs, TRPM8 rs10166942 T allele-carrying patients were more likely to have chronic migraine than non-T allele carriers in both discovery and replication cohorts and combined samples (33.7% vs. 25.8%, p = 0.004, aOR = 1.62). In addition, T allele carriers reported more allodynic symptoms than non-T allele carriers (3.5 ± 3.7 vs. 2.6 ± 2.8, p < 0.001). However, allodynia severity did not differ between episodic and chronic migraine patients. No further correlations between genetic variants and endophenotypes were noted for the other SNPs.ConclusionsTRPM8 may contribute to the pathogenesis of chronic migraine. However, our study did not support allodynia as a link between them. The underlying mechanisms deserve further investigations.
Highlights
Migraine, which is characterised by recurrent pulsatile headaches associated with nausea, vomiting, photophobia, and phonophobia, is a common yet disabling disease [1] that can be clinically diagnosed using the proposed criteria in the International Classification of Headache Disorders (ICHD) [2]
We evaluated the cutaneous allodynia profile in patients with migraine using a 17-item questionnaire, aiming to obtain the evidence for the association between genetic variants and cutaneous allodynia, a clinical marker signaling the sensitisation of trigeminovascular system and a potential predictor of migraine chronification [19]
Among the six investigated Single nucleotide polymorphism (SNP), we found that only transient receptor potential melastatin 8 (TRPM8) variant rs10166942 was associated with chronic migraine
Summary
Migraine, which is characterised by recurrent pulsatile headaches associated with nausea, vomiting, photophobia, and phonophobia, is a common yet disabling disease [1] that can be clinically diagnosed using the proposed criteria in the International Classification of Headache Disorders (ICHD) [2]. Several single nucleotide polymorphisms (SNPs) associated with migraine. No susceptible gene has been identified to be associated with chronic migraine to date. Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. Evidences for their associations with migraine endophenotypes or subtypes are scarce. We aimed to investigate the associations of pre-identified migraine susceptibility loci in Taiwanese with migraine endophenotypes or subtypes, including chronic migraine and allodynia
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