TRPM2 in the Brain: Role in Health and Disease.

Giulia Sita,Gloria Ravegnini,Agnese Graziosi,Fabiana Morroni,Patrizia Hrelia

doi:10.3390/cells7070082

Giulia Sita, Gloria Ravegnini + Show 3 more

Open Access

https://doi.org/10.3390/cells7070082

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Journal: Cells	Publication Date: Jul 22, 2018
Citations: 33	License type: CC BY 4.0

Affiliation: University of Bologna

Abstract

Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca2+). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.

Highlights

Transient receptor potential (TRP) proteins form non-selective cation channels which are involved in several cell functions in activated form
Figure of the mainmain mechanisms modulated by TRP-melastatin 2 (TRPM2) in acute in neurodegenerative diseases
Shimizu et al demonstrated the important contribution of TRPM2 in CI, especially in Interestingly, Shimizu et al demonstrated the important contribution of TRPM2 in CI, especially males, suggesting a sex difference in the role of TRPM2 in ischemic cell death [107]

Summary

Introduction

Transient receptor potential (TRP) proteins form non-selective cation channels which are involved in several cell functions in activated form. Most TRP channels have a role in sensory perception in animals and they all share structural similarities [2] They contain six transmembrane regions with the C- and N-termini located intracellularly. They function mostly as heterotetramers or homotetramers that form a central ion permeation path between the fifth and sixth regions [3]. These channels are non-selective polymodal cation channels that are located in the plasma membrane. After a brief insight in the main features of TRPM2, we focused on the role of this protein in aging and in common chronic and acute neurodegenerative diseases

TRPM2 inside the Brain

TRPM2 outside the Brain

Role of TRPM2 in Brain Diseases

Chronic Neurodegenerative Diseases

Acute Neurodegenerative Diseases

Future