Abstract
Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP super family, is expressed in a subset of sensory neurons in the trigeminal, nodose, and dorsal root ganglia and implicated as a mediator of nociception evoked by diverse peripheral stimuli including noxious cold and pungent chemicals. We hypothesized that TRPA1 would be involved in detecting environmental chemicals to avoid taking in such a threat. To test our hypothesis, we did place preference test using TRPA1 knockout (KO) mice and age matched wild-type (WT) mice.
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