Abstract
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family includes 28 isoforms activated by physical and chemical stimuli, such as temperature, pH, osmotic pressure, and noxious stimuli. Recently, it has been shown that TRP channels are also directly or indirectly activated by reactive oxygen species. Oxidative stress plays an essential role in neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, and TRP channels are involved in the progression of those diseases by mechanisms involving changes in the crosstalk between Ca2+ regulation, oxidative stress, and production of inflammatory mediators. TRP channels involved in nociception include members of the TRPV, TRPM, TRPA, and TRPC subfamilies that transduce physical and chemical noxious stimuli. It has also been reported that pain is a complex issue in patients with Alzheimer’s and Parkinson’s diseases, and adequate management of pain in those conditions is still in discussion. TRPV1 has a role in neuroinflammation, a critical mechanism involved in neurodegeneration. Therefore, some studies have considered TRPV1 as a target for both pain treatment and neurodegenerative disorders. Thus, this review aimed to describe the TRP-dependent mechanism that can mediate pain sensation in neurodegenerative diseases and the therapeutic approach available to palliate pain and neurodegenerative symptoms throughout the regulation of these channels.
Highlights
Specialty section: This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
TRPV1 has a role in neuroinflammation, a critical mechanism involved in neurodegeneration
Transient receptor potential (TRP) channels are part of cellular pathways related to the synthesis of many inflammatory mediators associated with neuroprotection/neurotoxicity, where they contribute to intracellular calcium regulation and signaling and painful stimuli transduction (Ji and Suter, 2007; Miyake et al, 2014; Lee and Kim, 2017)
Summary
Milena Duitama†, Viviana Vargas-López†, Zulma Casas, Sonia L. Transient receptor potential (TRP) are cation channels expressed in both non-excitable and excitable cells from diverse tissues, including heart, lung, and brain. TRPV1 has a role in neuroinflammation, a critical mechanism involved in neurodegeneration. This review aimed to describe the TRP-dependent mechanism that can mediate pain sensation in neurodegenerative diseases and the therapeutic approach available to palliate pain and neurodegenerative symptoms throughout the regulation of these channels. Numerous excitable and non-excitable tissues express TRPs, where they are involved in sensory signal transduction (nociception, taste, pressure, temperature, vision, and pheromone signaling), as well as homeostatic regulation (muscle contraction, vessel relaxation, and cell proliferation) (Gees et al, 2010). In the central nervous system (CNS), several TRP channels are expressed in both neurons and glia, fulfilling critical roles in neurogenesis, structural/functional plasticity, and cell homeostasis (Nilius, 2012; Vennekens et al, 2012; Katz et al, 2017)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
