TRP channels and thermosensation.

Abstract

Several TRP channels exhibit highly temperature-dependent gating properties, which leads to steep changes in depolarising current upon either cooling or heating. Based on this characteristic feature, these so-called "thermoTRPs" have been widely studied with the aim to elucidate their potential key role as thermosensors in the somatosensory system and to understand the basis of their high thermal sensitivity. In this chapter, I provide a brief critical overview of current knowledge on the role of TRP channels in thermosensing and on the thermodynamic and molecular basis of their steep temperature dependence.