Abstract

The comorbidity between bipolar disorders and epilepsy knows a growing interest not only because of the probable neurochemical underpinnings of those two disorders but also because of the better research of the bipolar spectrum symptoms among the epileptic patients. We report two interesting cases. The first one is a 17 year old teenager suffering from a bipolar disorder I and of a symptomatic (cerebral palsy) right fronto-temporal epilepsy. The manic episode subsided thanks to carbamazepine treatment. The second case is a 19-year-old man suffering from a rapid cycling bipolar disorder II and from a symptomatic (cerebral palsy) generalized epilepsy. The depressive episode subsided thanks to parotexine treatment. The mood and epileptic stabilization has been obtained thanks to valproate of sodium. These two case reports are discussed from a diagnostic and therapeutic point of view and they are followed by a review of the physiopathological hypotheses. Considering the high prevalence of the bipolar spectrum, treating the bipolar symptoms is a major issue for the epileptic patients quality of life.

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