Troponin I and D-Dimer levels in preeclampsia and eclampsia: prospective study

Abstract

Objective: The aim of this study was to evaluate serum cardiac troponin I and D-Dimer (D-Di) levels in preeclampsia (PE), eclampsia(E), and normotensive healthy pregnant women in third trimester in order to define their diagnostic value. Materials and Methods:The study group consisted of 42 preeclamptic patients and 16 eclamptic patient; 108 healthy normotensive pregnant women in thirdtrimester who were chosen from outpatients clinic and examined regularly used as a control group. Serum cardiac troponin I and D-Dilevels were measured using an immunoassay. Results: The average levels of troponin I were 0.0134 ± 0.0091, 0.017 ± 0.0085, 0.180 ±0.136 in control group, preeclamptic, and eclamptic patients, respectively. The levels of troponin in eclamptic patients were statisticallyhigher than the normotensive and preeclamptic group (p = 0.016, p = 0.014). There were no differences in terms of troponin I level betweenpreeclamptic group and normotensive pregnant women in third trimester (p = 0.089). The average D-Di levels were 634 ± 228ng/ml, 1426 ± 430 ng/ml, 2067± 580 ng/ml in control group, preeclamptic, and eclamptic patients, respectively. The levels of D-Di inpreeclamptic and eclamptic patients were found significantly higher than the control groups (p = 0.034, p = 0.020). Conclusion: Serumtroponin I levels increased in eclamptic patient because of myocardial damage. An increased level of troponin was not detected inpreeclamptic patients. However; D-Di level increased in preeclamptic and eclamptic patients.