TROPION-Lung01 Results Indicate PFS Benefit With Datopotamab Deruxtecan Over Docetaxel in Previously Treated Nonsquamous NSCLC: A Critique and a Question

Abstract

This commentary aims to point out how the results of the TROPION-LUNG01 study stress the "positive aspects" of the results, specifically, the increase in PFS, but hardly mention the potential harm to patients with squamous histology and lacks information on binary data (progression-free / progression, alive/death) as per CONSORT guidelines. Here, we also remark on the need for adherence to CONSORT guidelines to inform on the absolute and relative risks of Randomized Controlled Trials (RCT). We emphasize the need for further research to develop a framework of how oncologists might explain the differences between PFS and OS in simple terms for a lay audience to create a more thoughtful decision of patients to embark on any cancer treatment.