TROPHY registry \u2014 status report

Ulrich-Wilhelm Thomale ,António Ferreira ,А Б Кабаньян ,Raphaël Guzman ,Ahmed El Damaty ,Martin U Schuhmann ,A G Sukharev ,Nunthasiri Wittayanakorn ,Rolando Jiménez-Guerra ,Sandi Lam ,Pietro Spennato ,Andreas Schaumann ,Dennis R Buis ,A Seliverstov,Thomas Beez ,Jonathan Roth ,Javier Márquez-Rivas ,Sarah Stricker ,E Bogoslovskaia,C Dziugan,Шулаев Алексей Владимирович ,M Sáez ,Shlomi Constantini ,Tomáš Radovnický ,Onur Özgüral ,S K Gorelyshev ,Christoph Bührer ,Steffen Fleck ,Giuseppe Cinalli ,Spyros Sgouros ,Petr Vacek ,Stefan Linsler ,C Auer ,Christoph Wiegand ,Gökmen Kahiloğulları ,Philine Behrens ,Mohamed Azab ,Sérgio Cavalheiro ,Abhaya V Kulkarni ,A A Alexeev ,Mykhailo Lovha ,Hans Bock

doi:10.1007/s00381-021-05258-w

Abstract

IntroductionThe TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration.MethodsOn the standard of treatment forms, each center indicated the institutional protocol of interventions performed for neonatal post-hemorrhagic hydrocephalus (nPHH) for a time period of 2 years (Y1 and Y2) before starting the active participation in the registry. In addition, the amount of patients enrolled so far and allocated to a treatment approach are reported.ResultsAccording to the standard of treatment forms completed by 56 registered centers, fewer EVDs (Y1 55% Y2 46%) were used while more centers have implemented NEL (Y1 39%; Y2 52%) to treat nPHH. VAD (Y1 66%; Y2 66%) and VSGS (Y1 42%; Y2 41%) were used at a consistent rate during the 2 years. The majority of the centers used at least two different techniques to treat nPHH (43%), while 27% used only one technique, 21% used three, and 7% used even four different techniques. Patient data of 110 infants treated surgically between 9/2018 and 2/2021 (13% EVD, 15% VAD, 30% VSGS, and 43% NEL) were contributed by 29 centers.ConclusionsOur results emphasize the varying strategies used for the treatment of nPHH. The international TROPHY registry has entered into a phase of growing patient recruitment. Further evaluation will be performed and published according to the registry protocol.

Highlights

The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines
From September 2018 to February 2021, a total of 56 centers completed an eligibility form stating the standard treatment each center used before active participation in TROPHY
In terms of international distribution for registration, the three most active countries are Germany, Russia, and the USA, while the most actively contributing countries are Russia, Germany, and Italy as well as Austria (Fig. 1A, B). For these 56 centers, the number of annual interventions per center according to the standard treatment forms was 35 ± 42 neurosurgical interventions for both years and 9 ± 14 neuroendoscopic interventions in year 1 (Y1) and 11 ± 16 in year 2 (Y2)

Summary

Introduction

The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL) This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration. The long-term goal of the TROPHY registry is to contribute substantial data to further develop treatment guidelines for neonates with posthemorrhagic hydrocephalus [5] This status report presents the data resulting from the standard of treatment forms to show the distribution of surgical techniques used at the participating centers before active participation as well as the current status of data collection indicated by the number of centers and patients included so far in the TROPHY registry

Methods

Results

Conclusion