Abstract
The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC.
Highlights
Gastric cancer (GC) is a leading cause of global cancer-related mortality [1]
Trop2 mRNA was overexpressed in GC tissues
Trop2 mRNA expression was 2.32 ± 1.44 fold higher in GC tissues than in matched tumor neighbor tissues (p < 0.001, Figure 1)
Summary
Gastric cancer (GC) is a leading cause of global cancer-related mortality [1]. GC prevalence is highest in Asia, and the majority of GC patients are diagnosed at an advanced stage [2,3]. Due to the high rates of metastasis and recurrence, the prognosis of GC patients is poor: 5-year survival rates are less than 20% [4]. Helicobacter pylori (H. pylori) infection and intestinal metaplasia (IM) are common complications in gastric cancer patients [5,6,7,8]. Identifying new genetic markers to help diagnose GC earlier will help to improve cure rates and reduce complications, including H. pylori and other chronic gastric infections. The human trophoblast cell surface (TACSTD2/ Trop2/M1S1/GA733–1) gene is located at chromosome www.impactjournals.com/oncotarget
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
