Abstract
In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).
Highlights
Parkinson disease (PD) is due to the progressive degeneration of dopaminergic neurons in the midbrain, and the affected neurons contain inclusions called Lewy bodies (LBs) and Lewy neurites (LNs) that are filled with aggregates and amyloid fibers of the presynaptic protein alpha-synuclein (α-syn) [1]
Braak showed that LB/LN pathology develops in the enteric nervous system of PDApUati:enPtesr,PanLdOhSsetyhlyep;osuthbejesicztesdsh“otuhladtnaoptbuetuatsievdefoenrhvuirmonan- patients:Ther
The α-syn protein is composed of 3 domains: an amphipathic domain; the hydrophobic NACAdUom: aPinle(ansoedne-fAinβecNoAmCpionntheensteonfteAnlczehTehimeaerÀ AdUsisyen:apsPreoeprtePlaiLnqiOusecSsos,mtryeplesoi;dseeupdeoosnf6y31mdiocmdiasienass:en
Summary
Parkinson disease (PD) is due to the progressive degeneration of dopaminergic neurons in the midbrain, and the affected neurons contain inclusions called Lewy bodies (LBs) and Lewy neurites (LNs) that are filled with aggregates and amyloid fibers of the presynaptic protein alpha-synuclein (α-syn) [1]. These 3 studies and others [5,6] have led the field to Published: July 20, 2021 the current paradigm, i.e., a gut-related insult triggers α-syn to form cytotoxic, prion-like conformers that spread along the gut–brain axis.
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