Abstract
tRNA Splicing
Highlights
Introns interrupt the continuity of many eukaryal genes, and their removal by splicing is a crucial step in gene expression
It seems likely that the Group 2 and nuclear mRNA splicing reactions have diverged from a common ancestor. tRNA genes are interrupted by introns, but here the splicing mechanism is quite different because it is catalyzed by three enzymes, all proteins and with an intrinsic requirement for ATP hydrolysis
Studies on the structure of yeast tRNA precursors showed that the conformation of the mature domain is retained suggesting the model of the tertiary structure of eukaryal pre-tRNA shown in Fig. 1A [9, 10]
Summary
Introns interrupt the continuity of many eukaryal genes, and their removal by splicing is a crucial step in gene expression. TRNA genes are interrupted by introns, but here the splicing mechanism is quite different because it is catalyzed by three enzymes, all proteins and with an intrinsic requirement for ATP hydrolysis. It has been found that the first enzyme in the tRNA splicing pathway, the tRNA endonuclease, has been conserved in evolution since the divergence of the Eukarya and the Archaea.
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