Türk Popülasyonunda Disfaji ile Başvuran Hastalarda Eozinofilik Özofajit Sıklığı

Abstract

Objective: In this study we aimed to investigate the prevalence of eosinophilic esophagitis (EoE) among patients with dysphagia in the Turkish population. Material and Methods: Patients with dysphagia were enrolled in the study. The enrolled patients underwent esophagogastroduodenoscopy and esophageal biopsies were obtained-one from proximal and one from mid-esophagus. Esophageal motor disorders (EMD) which can cause dysphagia (achalasia etc) were excluded by esophagial manometry. The diagnosis of EoE was made when patients had chronic esophageal symptoms and the esophageal biopsy showed >15 eosinophils/high-power field (HPF). Results: A total of 107 patients with dysphagia were enrolled in the study. After exclusion of patients with EMD and other structural or systemic diseases, 55 patients were left in the study. Ten of 55 patients (18.2%) were male and the median age of patients was 45 (18-80) years. All patients had dysphagia. Overall 37 (67.3%) had regurgitation, 35 (63.6%) pyrosis, 9 (16.4%) epigastric pain, 17 (30.9%) nausea and one patient (1.8%) had vomiting. In the initial routine histopathological examination, five patients reported to have eosinophilic esophagitis but re-evaluation of histopathological findings revealed that only one patient met the diagnostic criteria for Eosinophilic Esophagitis (EoE). However, gastric biopsy of this patient showed intense eosinophilic infiltration and the diagnosis of eosinophilic gastroenteritis was more likely in that patient. Conclusion: As a result, despite the small number of patients, eosinophilic esophagitis is suggested to be one of the least common causes of dysphagia among adult patients in the Turkish population.