Trivariate compound generalized poisson model for corticotropin-releasing hormone effects on human pregnant and nonpregnant

Abstract

In this paper, we apply a new approach to uterine contractions to a large panel of human pregnant non pregnant myometrial strips, treated or not by corticotropin releasing hormone (CRH). This model is based on a fine analysis of the contraction curves.This analysis yield four mathematical parameters beta, theta, tau1 and tau2 related to excitability, duration of plateau phase, and time constants for relaxation describing respectively, the different portions of the contraction cycle. This leads to specific differences in spontaneous contractile activity between pregnant and nonpregnant states. In the present study, we compare nonpregant and pregnant women close to the term vitro CRH myometrial responsiveness, to describe uterine contractile activity during a parturition. We have a Trivariate compound generalized Poisson model for uterine contraction to a pregnant and nonpregnant myometrial strips, treated or not treated by corticotrophin- releasing hormone (CRH). Although, the biochemical signification of these results remains to be elucidated, we contribute to emphasize CRH action at the myometrical level. The results reveal highly significant differences between pregnant and nonpregnant myometrium as well as in their response to CRH.