Trityl chloride as an efficient organic catalyst for one-pot, five-component and diastereoselective synthesis of highly substituted piperidines

Abstract

Trityl chloride is used as an efficient organic catalyst for the one-pot, five-component and diastereoselective synthesis of highly substituted piperidines by means of reaction between aromatic aldehydes, amines and β-ketoesters in methanol at 50 °C. The structure as well as relative stereochemistry of products was confirmed by single X-ray crystallographic analysis. This homogeneous catalyst procedure includes some important aspects like the easy work-up, diastereoselectivity, simple and readily available precursors, inexpensive catalyst, relatively short reaction time, and good to high yields.