Abstract
AbstractSteroids with diazo and azido functional groups were labeled with tritium atoms by microwave discharge activation of tritium gas. The specific activity of the products was increased by maximizing the exposure surface using glass fiber paper for dispersion, reducing the amount of sample to be exposed. and increasing tritium pressure. A 500 fold increase in specific activity was achieved in dispersed sample as compared to the solid. Addition of tritium atoms to 4,5 double bond in Δ4‐3‐keto steroid occurred, giving rise to a mixture of 5α‐ and 5β‐isomers in about equal quantities.
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