Abstract
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
Highlights
The sodium salt of trithiocyanuric acid (ttcH3 = trithiocyanuric acid, named as2,4,6-trimercapto-1,3,5-triazine (TMT)) readily forms precipitates with heavy metal ions and that is why it is used for removal of heavy metal ions from industrial wastewater
We expected the formation of a binuclear or polynuclear complex with a trithiocyanurate bridge, only a mononuclear Fe(II) complex was formed
Its composition was proposed on the base of elemental analysis and unambiguously confirmed by single crystal X-ray analysis
Summary
Removal of residual palladium and its compounds from reaction mixtures in preparation of drugs, in which palladium is used as a catalyst, is very important [5,6]. Biological activity of trithiocyanuric compound was evaluated as it can serve as a ligand of Toxoplasma gondii orotate phosphoribosyltransferase [7,8,9]. This enzyme is necessary for replication of the parasitic protozoan Toxoplasma gondii, which causes the disease toxoplasmosis. In addition to the structural, electrochemical and spectral study, interaction of the complexes with the circular and linear forms of p-Bluescript DNA was reported. The Ru(II) complexes reduced the fluorescence intensity of both circular and linear DNA.
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