Abstract
Euphorbia maculata is a medicinal plant of the Euphorbiaceae family, which can produce anti-inflammatory and cancer chemopreventive agents of triterpenoids. The present study reports on the bioactive triterpenoids of this plant. Two new lanostane-type triterpenoids, named (3S,4S,7S,9R)-4-methyl-3,7-dihydroxy-7(8→9) abeo-lanost-24(28)-en-8-one (1) and 24-hydroperoxylanost-7,25-dien-3β-ol (2), together with 15 known triterpene derivatives, were isolated from Euphorbia maculata. The structures of the new compounds were determined on the basis of extensive spectroscopic data (UV, MS, 1H and 13C-NMR, and 2D NMR) analysis. All tetracyclic triterpenoids (1–11) were evaluated for their anti-inflammatory effects in the test of TPA-induced inflammation (1 μg/ear) in mice. The triterpenes exhibited significant anti-inflammatory activities.
Highlights
Euphorbia maculata L. is a plant of the Euphorbiaceae family, which is widely used as folk medicine throughout the world, especially in China, Japan, and Korea [1]
As many tumor promoters can cause inflammatory symptoms, the inhibitory effect against TPA-induced ear inflammation has a close correlation with the inhibition of TPA-induced tumor promotion in a two-stage carcinogenesis
We chose the medicinal plants of the genus Euphorbia (Euphorbiaceae) which contained triterpenoids to study their chemical constituents and pharmacological activity [11]
Summary
Euphorbia maculata L. is a plant of the Euphorbiaceae family, which is widely used as folk medicine throughout the world, especially in China, Japan, and Korea [1]. E. maculata is an annual herb that is commonly used for the treatment of diarrhea, hemoptysis, hematuria, and sore swollen [2]. Extracts of this plant has an antiplatelet activity via suppressing thromboxane B2 formation [3]. Many triterpenoids of different skeletons exhibited anti-inflammatory and inhibitory activities on tumor promotion induced by TPA [8,9,10]. We chose the medicinal plants of the genus Euphorbia (Euphorbiaceae) which contained triterpenoids to study their chemical constituents and pharmacological activity [11]. Molecules 2018, 23, 2112 and the predominant triterpene in this plant, euphol, significantly inhibited the tumor-promoting activity induced by TPA [12]. We describe the structural elucidation of the new triterpenoids and the anti-inflammatory activities of all tetracyclic isolated triterpenoids
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