Abstract
From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine ( 1), buxhyrcamine ( 2), and 31-demethylcyclobuxoviridine ( 3), along with 16 known compounds, cyclobuxoviridine ( 4), N b-dimethylcyclobuxoviricine ( 5), E-buxenone ( 6), Z-buxenone ( 7), moenjodaramine ( 8), homomoenjodarmine ( 9), buxamine A ( 10), buxamine B ( 11), 31-hydroxybuxamine B ( 12), N 20-formylbuxaminol E ( 13), papillozine C ( 14), buxmicrophylline F ( 15), buxrugulosamine ( 16), cyclobuxophylline O ( 17), spirofornabuxine ( 18) and arbora-1,9(11)-dien-3-one ( 19) were isolated. Their structures were elucidated by using NMR spectroscopic methods. All of the compounds exhibited moderate to weak acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory activities. Compounds 1– 19 also exhibited modest anti-fungal activities against Candida albicans. Compounds 1, 2, 8, 9 and 18 also exhibited weak anti-leishmanial activity.
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