Abstract
A new triterpenoid saponin, named terpengustifol A (1), and two new lignan glucosides, phengustifols A and B (2 and 3), were isolated from the flowers of Elaeagnus angustifolia. Their structures were determined by the extensive analysis of the spectroscopic data (including NMR and HRMS) and ECD calculations. Compound 1 possesses an unusual monoterpene (Z)-6-hydroxy-2,6-dimethylocta-2,7-dienoyl unit at C-21. Compounds 2 and 3 are a pair of diastereoisomers, while their aglycones are a pair of enantiomers. Compounds 1 and 2 exhibited moderate cytotoxic activities against A375 cell lines with IC50 values at 12.1 and 15.6 μM, respectively. This is firstly reported the triterpenoid saponin and lignans isolated from the Elaeagnus angustifolia flowers.
Highlights
Elaeagnus angustifolia L., commonly called oleaster or Russian olive, is a medicinal plant belonging to the Elaeagnacea family
Zeinalzadeh et al reported a randomized clinical trial to compare the effect of E. angustifolia flower capsule and sildenafil citrate tablet on sexual interest/arousal disorder [7]
Compound 1 was isolated as white powder; its molecular formula was identified as C69 H110 O29 by the pseudomolecular ion peak at m/z 1447.6933 [M + HCOO]- in the HRESIMS spectrum
Summary
Elaeagnus angustifolia L., commonly called oleaster or Russian olive, is a medicinal plant belonging to the Elaeagnacea family. It is widely distributed from the northern regions of Asia to the Himalayas and Europe [1]. E. angustifolia is mainly planted in various provinces of Northwest of China, for wind breaks and sand fixation [2]. The flowers of E. angustifolia were traditionally used to treat asthma and tetanus in Iran and China [3,4,5]. In Chinese Uygur medicine, E. angustifolia flowers were considered as dry and hot materials, which is mainly used to treat brain disease, thoracalgia and asthma in the clinic.
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