Triterpenoid compound from metanol extract of mangrove leaves (Sonneratia alba) and anti-cholesterol activity test

Weny J.A Musa,Saronom Silaban,Nurhayati Bialangi,Boima Situmeang

doi:10.24114/jpkim.v11i1.13124

Weny J.A Musa, Saronom Silaban + Show 2 more

Open Access

https://doi.org/10.24114/jpkim.v11i1.13124

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Abstract

Mangrove plant ( Sonneratia alba ) is easily found in West and North Indonesia. Mangrove plant has the potential of being a herb medicine. Mangrove plant variously used in ethnomedicine to treat various deseases like wounds, diarrhea, and fever. In previously sutudy, leaf extract of mangrove plants reported have anti-cholesterol activity. This plant is widely used to treat various deseases like wounds, diarrhea, and fever. The purpose of this study was to isolate triterpenoid compound from the ethyl acetate fraction of mangrove leaves and anticholesterol activity test. Extraction was done by maceration method using methanol 96% as solvent. Isolation was carried out by column chromatography using a combination of n -hexane, ethyl acetate, and methanol solvents. The elucidation of the structure was determined by analysis of IR, 1 H-NMR, 13 C-NMR, 2D-NMR, and MS spectroscopies as well as by comparisons with the literature. Anticholesterol activity test was carried out in vitro. The results showed that triterpenoid compounds (lupeol) were able to reduce cholesterol from concentrations of 5, 10, 20, 40, 60, and 80 ppm are 13.7; 29.4; 49.0; 60,1; 70.2; and 77.0% respectively. Therefore, isolates compound (lupeol) have anti-cholesterol activity. Keywords: Anti-cholesterol; mangrove; triterpenes

Highlights

Mangrove plants (Sonneratia alba) are a group of plants that have high or shrubs and grow in tropical and subtropical coastal areas
Sonneratia alba widely distributed in the coastal regions of Southeast Asia and the Indian Ocean
This plant has been used traditionally in coastal communities of Indonesia to treat of wounds, diarrhea, and fever deseases (Prabhu & Guruvayoorappan, 2012)

Summary

Introduction

Mangrove plants (Sonneratia alba) are a group of plants that have high or shrubs and grow in tropical and subtropical coastal areas. Phytochemical investigation Sonneratia alba has been reported contained triterpenoid, steroid, The trend of eating practical and instant foods like fast food and preserved food has developed rapidly in the community. The types of this food can harm the human bodies, because it contains saturated fatty acids and high cholesterol. Based on WHO data (2011) cardiovascular disease is the biggest cause of death in worldwide. It is estimated that in 2030 that 23.6 million people worldwide will die of cardiovascular disease

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