Abstract
Foliar buds represent a new category of vegetal products, used in modern phytotherapy as hydro-glycero-ethanolic extracts [1,2]. Foliar buds of birch tree Betula pendula Roth were analyzed, regarding polyphenolic structures analysis, qualitative analysis of triterpenic structures and in vitro antitumour activity on cell lines A431 and MCF7. The Folin-Ciocalteu method [3,4] was used to determine total content of polyphenols and a series of 19 standards was used for the HPLC-MS analysis. The TLC chromatography and FT-IR spectroscopy were used for the analysis of triterpenic structures. Birch tree foliar buds contain 545mg/100g total polyphenols. TLC and FT-IR analysis emphasized the presence of triterpenic structures in dry extract of foliar buds. In vitro studies on tumour cell lines: skin cancer A431 and breast cancer MCF7 prove that foliar buds extract (5% in DMSO) causes the inhibition of tumoral proliferation. The study showed that HPLC-MS can be successfully used to determine total content in polyphenols and TLC and FT-IR analysis emphasized the presence of triterpenic structures in dry extract of foliar buds. Foliar buds extract in DMSO shows in vitro antineoplasic activity.
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