Abstract
In our preliminary screening study on the anti-inflammatory activity, a new triterpene compound, aceranol acetate ( 1), was isolated along with five known compounds: β-amyrin acetate ( 2); glutinol acetate ( 3); friedelin ( 4); glutinol ( 5); (3β)- d-glucopyranoside-stigmast-5-en-3-yl ( 6), from the stems and leaves of Acer mandshuricum. The structure of the new triterpene was determined to be 5α,6α-epidioxy-5β,6β-epoxy-9,13-dimethyl-25,26-dinoroleanan-3β-ol acetate by spectroscopic studies. Compounds 2– 6 were isolated from this plant for the first. Five triterpene compounds ( 1– 5) showed significant cytotoxic activity with GI 50 in the range of 11.1–17.9 μM, whereas steroid compound ( 6) exhibited moderate activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29). Furthermore, the anti-inflammatory effects of compounds 1– 6 in the non-cytotoxic concentrations (1–100 nM) were evaluated for the inhibitory activity of TNF-α secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. Among the compounds tested, compound 2 showed the strongest anti-inflammatory activity with the inhibition rate up to 38.40% at the concentration of 100 nM, whereas other five compounds ( 2– 6) exhibited moderate activity.
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