Abstract
Two mononuclear Co(III) complexes, [Co(L1)3] (1) and [Co(L2)3] (2) (HL1, 2-[(2-methoxy-ethylimino)-methyl]-phenol; HL2, 1-[(2-methoxy-ethylimino)-methyl]-naphthalen-2-ol) have been synthesized and characterized by X-ray crystal structure determination, IR and mass spectroscopic techniques. Both the complexes are mononuclear with distorted octahedral geometries and the Co(III) center are coordinated with three bidentate (O, N) Schiff base ligands. Complexes 1 and 2 form 1D and 3D supramolecular structures, respectively, with weak CH…π interactions. Experimental UV–vis absorption spectra have been compared with the results obtained from DFT / TD-DFT calculation using B3LYP functional and LanL2DZ basis set. The interaction of the complexes with bovine serum albumin (BSA) and human serum albumin (HSA) were studied using electronic absorption and fluorescence spectroscopic methods and the results show that complexes potentially quench the fluorescence of BSA/HSA through ground state association mechanism. Cytotoxicity studies of these complexes have been performed against breast cancer cell lines and found that they have moderate anticancer activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.