Abstract
The title trinuclear nickel(II) complex, [Ni3(C10H11NO2S)3]·C3H7NO, with a Schiff base ligand formed in situ from 2-amino-ethane-thiol and o-vanillin crystallizes in the ortho-rhom-bic space group Pbca. Its asymmetric unit consists of one neutral Ni3 L 3 mol-ecule and one DMF solvent mol-ecule. The solid-state organization of the complex can be described as an insertion of the solvent mol-ecules within the crystallographically independent trinuclear NiII species. Several C-H⋯π edge-to-face inter-actions and π-π stacking inter-actions link the components in the crystal. A first example of a short inter-molecular C-H⋯Ni contact is found. Anti-bacterial in vitro screening revealed that the title compound has anti-bacterial activity, the best effect being against Acinetobacter baumannii.
Highlights
Chemical contextSchiff base ligands are one of the most widely utilized classes of ligands in metal coordination chemistry because of their preparative accessibility, structural variety and strong metalbinding ability with many metal ions via azomethine HC N or phenolic groups (Garnovskii et al, 1993; Bera et al, 1998; Prabhakaran et al, 2004). o-Vanillin-based Schiff ligands demonstrate an exceptionally rich coordination chemistry and diverse properties – magnetism, luminescence, chirality, catalysis, cytotoxicity and ferroelectricity (Andruh, 2015)
The title trinuclear nickel(II) complex, [Ni3(C10H11NO2S)3]ÁC3H7NO, with a Schiff base ligand formed in situ from 2-aminoethanethiol and o-vanillin crystallizes in the orthorhombic space group Pbca
Its asymmetric unit consists of one neutral Ni3L3 molecule and one DMF solvent molecule
Summary
Schiff base ligands are one of the most widely utilized classes of ligands in metal coordination chemistry because of their preparative accessibility, structural variety and strong metalbinding ability with many metal ions via azomethine HC N or phenolic groups (Garnovskii et al, 1993; Bera et al, 1998; Prabhakaran et al, 2004). o-Vanillin-based Schiff ligands demonstrate an exceptionally rich coordination chemistry and diverse properties – magnetism, luminescence, chirality, catalysis, cytotoxicity and ferroelectricity (Andruh, 2015). The N and S atoms play a key role in the coordination of metals at the active sites of numerous metallobiomolecules. It has been shown that ONS Schiff bases are moderately active against leukemia (Tofazzal et al, 2000). Nickel complexes with a multidentate NSO-containing mixed-ligand environment attract attention because such complexes play an important role in bioinorganic chemistry and redox enzyme systems and can be considered as model objects for studying the active sites of biological systems (Halcrow et al, 1994). In this work we present the crystal structure of a novel trinuclear NiII complex with an NSO-type Schiff base ligand derived from o-vanillin and 2-aminoethanethiol as well results of its antibacterial activity screening against several Gram-positive and Gram-negative bacteria
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
