Abstract
s / Pancreatology 13 (2013) S2–S98 S14 Results: Pancreatic damage in the initial phase was comparable in both animal strains. In contrast to the early phase, C5-/mice displayed reduced pancreatic fibrosis in both models. Histology showed decreased collagen I and a smooth muscle actin (aSMA) staining. Also the amount of Ki67 positive cells was decreased in C5-deleted animals. In pancreatic tissue of wild type animalswith chronic pancreatitis C5a receptor and aSMApositive PSCs were observed by fluorescence staining. Isolated PSCs could be activated with C5a showing increased aSMA expression and decreased proliferation. Conclusion: C5 is an important regulator for the development of pancreatic fibrosis during chronic pancreatitis, but does not contribute to the severity of the disease during the acute phase. C5a has direct effects on fibrosis by activating PSCs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
