Abstract

Objective Body mass index (BMI) and tri-ponderal mass index (TMI) are anthropometric measures to evaluate body adiposity in the various age groups. The present study aims to compare the predictive value of TMI and BMI for metabolic syndrome (Mets) in children and adolescents of both genders. Subjects and methods A cross-sectional study conducted on 3731 Iranian children and adolescents aged 7-18 years obtained from the fifth survey of 'Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease' (CASPIAN-V) study. The predictive value of BMI and TMI for MetS were determined using Receiver-operator curves. Logistic regression analysis was used to assess the relationship between these indices with MetS. Results 52.6% of participants were boys. The mean (standard deviations) age for boys and girls were 12.62 (3.02) and 12.25 (3.05) years, respectively. In boys, the area under the curve (AUC) of TMI was greater than BMI for all age groups. AUC of TMI was also greater than BMI for age group of 11-14 years (AUC = 0.74; 95% CI (0.67, 0.81)) in girls. Furthermore, our findings showed that odds ratio of Mets for TMI was greater than BMI in age groups of 11-14 years (OR = 1.33 vs 1.22) and 15-18 years (1.16 vs 1.15) in girls and boys, respectively. Conclusion TMI and BMI had moderate predictive value for identifying MetS. However, TMI was a better predictor of MetS than BMI in both genders, especially in age groups of 11-14 and 15-19 years for girls and boys.

Highlights

  • Metabolic syndrome (MetS) is defined as a cluster of cardio metabolic risk factors, including central obesity, glucose intolerance, dyslipidemia and raised blood pressure [1]

  • In the age group of 15-18 years, mean of weight and height were significantly greater in boys than girls (p < 0.05) whereas mean of Body mass index (BMI) and tri-ponderal mass index (TMI) in girls was significantly greater than boys (p < 0.05)

  • To the best of our knowledge, this is the first study comparing the accuracy of TMI and BMI indices for metabolic syndrome (Mets) in pediatric population

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Summary

Introduction

Metabolic syndrome (MetS) is defined as a cluster of cardio metabolic risk factors, including central obesity, glucose intolerance, dyslipidemia and raised blood pressure [1]. MetS can occur from early life [2]. MetS has become a major health problem in children and adolescents; because of various factors including epidemiologic transition, double burden of nutritional disorders, and lifestyle changes. MetS is not limited to developed countries [3]. A systematic review determined the worldwide prevalence rates of MetS ranged between 0 and 19.2%. Previous studies indicated that MetS is a common metabolic disorder among Iranian children [5,6,7,8]. A systematic review reported prevalence rates of MetS in the range of 1-22% in Iran [9]

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