Abstract
Two-dimensional (2D) nanomaterials have raised significant interest in not only energy and environmental fields but also biomedical areas. Among these materials, one type that has many interesting properties and possesses numerous exciting applications is graphene oxide (GO)-based 2D materials. However, their poor stability in aqueous solutions and weak bioactivities limit their use in biomedical applications, especially antimicrobial fields. In this study, GO was functionalized with hydrophilic polymers and used as a vector for silver nanoparticles (Ag NPs) and sulfadiazine (SD). The stability of the material in aqueous solutions was greatly improved. The antibacterial activity of the novel hybrid antibacterial system (HAS) was enhanced by over 3 times compared to that of the system lacking SD. The antibacterial performance of the HAS was due to the triple synergy: bacterial capping, puncture, and inhibition. This study provides new insights into the design and fabrication of surface-modified GO and carbon materials and their 2D hybrid multifunctional materials for advanced applications including biomedical and especially antibacterial applications, broadening the design and application scope of carbon and 2D materials.
Highlights
Graphene oxide (GO), an important two-dimensional (2D) nanomaterial, has attracted extensive attention due to its unique physical, chemical, and biological properties[1,2]
We introduced SD and Ag NPs onto the surface of GO to improve the antimicrobial activity of the hybrid materials, taking advantage of the high specific surface area of GO
5 mL of the LB broth medium was mixed with 1% inoculum of activated bacteria, adding 1 mL of phosphate buffer, mixing evenly and diluting to a concentration of 105 colony-forming units (CFU)/mL to test the antibacterial properties of E. coli and S. aureus
Summary
Graphene oxide (GO), an important two-dimensional (2D) nanomaterial, has attracted extensive attention due to its unique physical, chemical, and biological properties[1,2]. GO has a high specific surface area and has many carboxylic groups at its edges[3,4]. Recent research has shown that graphene-based materials have low cytotoxicity and exhibit antibacterial activity[11,12,13]. The antibacterial properties and biomedical applications of these materials have been limited due to their low solubility in aqueous solution[14]. Recent studies have shown that smaller Ag NPs have a better antimicrobial effect[15]. Small Ag NPs coagulate limiting their biomedical applications. GO was chosen for loading Ag NPs because it has a high specific surface area and unique physicochemical properties
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
