Abstract
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and is reported as one of the most leading cause of disabilities and markedly contributes to a significant global burden o...
Highlights
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and is reported as one of the most leading cause of disabilities and markedly contributes to a significant global burden of the disease worldwide
Following the serotonin and norepinephrine reuptake inhibitors’ (SNRIs) relative success in treatment of MDD, researchers have pursued the idea of developing novel drugs blocking all three monoamine transporters, namely serotonin, NE, DA reuptake inhibitors, or triple reuptake inhibitors (TRIs)
Drug development in MDD alternatively could be of broadly targeted therapies such as TRIs that aspire to the efficacy of existing agents with the additional targeting of dimensions of psychopathology not adequately treated by existing antidepressants
Summary
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and is reported as one of the most leading cause of disabilities and markedly contributes to a significant global burden of the disease worldwide. Most current antidepressants selectively target monoamines serotonin, norepinephrine, or dopamine, which was linked to deficiencies in neurotransmission in the brains of depressed individuals while having limited effects on muscarinic and histamine receptors [2]. Drugs acting on several monoamine systems might more effectively restore dysfunctional networks in severe and chronic disorders through mirroring the multi-system operation of the brain [6,7,8].
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