Abstract
Triple Negative Breast Cancer (TNBC) is an aggressive variant of breast cancer with penurious prognosis and limited therapeutic options. This subtype is characterised with higher incidence rate among the younger women, aggressive tumour behaviour, with early local recurrence and distant metastasis leading to poor outcomes.
Highlights
The breast cancer [1] is one of the common cancers reported in Indian women and accounts for 14% of all other type of cancers in India [2,3]
Data for the meta-analysis were obtained from 16 primary studies which involves 9787 Indian patients mostly women treated with the invasive breast cancer
According to the pooled estimate prevalence of Triple Negative Breast Cancer (TNBC) in India is 25.04% which is higher in comparison to the western literature
Summary
The breast cancer [1] is one of the common cancers reported in Indian women and accounts for 14% of all other type of cancers in India [2,3]. The TNBC is an aggressive variant of breast cancer associated with poor health outcome which is identified by Immuno-Histochemistry (IHC) examination finding of missing expression of Progesterone Receptor (PR), Oestrogen Receptor (ER) and absence of amplification or over expression of the Human Epidermal Growth Factor Receptor 2 (HER 2). It presents with varied clinico pathological and molecular characteristics with poor prognosis and limited therapeutic options. This subtype is characterised with higher incidence rate among the younger women, aggressive tumour behaviour, with early local recurrence and distant metastasis leading to poor outcomes
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