Abstract
Triple-negative (basal-like) breast cancer: a new entity
Highlights
We developed a quantitative PCR (QPCR) technique for the detection of cytokeratin 19 (CK19) transcripts in blood and bone marrow and compared this with immunocytochemistry (ICC)
In 19 healthy individuals we found one CTC in the blood of tumor cells in metastatic breast cancer (MBC): biological two patients
Cancer specific survival (RR 6.3, 95% CI 2.3–17.6, P < 0.0001), References to nodal status at time of primary diagnosis (RR 2.9, 95% CI 1.8–4.7). 1
Summary
We developed a quantitative PCR (QPCR) technique for the detection of cytokeratin 19 (CK19) transcripts in blood and bone marrow and compared this with immunocytochemistry (ICC). The skin sparing approach to mastectomy, Methods We have examined the impact of local therapy on survival in originated in the early 1990s, has especially facilitated immediate patients presenting with stage IV breast cancer at initial diagnosis, reconstruction of the breast and resulted in a high standard of reporting to the National Cancer Database (NCDB) between 1990 and cosmetic outcomes. Our study at NMH (the largest reported to date examining this issue) finds that maintenance of a disease-free chest wall is associated with improved survival This further emphasizes the need for prospective randomized trials to establish the role of local therapy in the setting of metastatic breast cancer.
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