Abstract
The majority of patients with stable arterial hypertension require combination therapy which is supported by the clinical evidence. The established target levels of blood pressure below 130/80 mmHg are challenging and demand multiple drug combinations in a single patient. Therefore, the use of dual and triple combination therapy is getting wider, and rational triple fixed combinations are highly relevant. The updated guidelines on the diagnostics, management and treatment of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology confirm and recommend early and wider use of the fixed-dose drug combinations. The paper reviews the main practical issues of the use of combination therapy, including key questions of the change from free dose to fixed dose combinations and their rational choice.
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