Abstract
Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O − 2) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O − 2 production than other phenyltin compounds. The O − 2 production by the xanthine oxidase—acetaldehyde system was not inhibited by TPTCl. This finding indicates that TPTCl does not itself react with O − 2. Furthermore, TPTCl did not influence the isolated NADPH oxidase at all, though O − 2 production of neutrophils stimulated with PMA in the presence of TPTCl was inhibited. These results indicate that TPTCl inhibits the activation process of the O − 2 generating system.
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