Abstract
Transient receptor potential (TRP) channels are a family of Ca2+-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from ‘PubMed’ and ‘PIE the search’ (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using ‘Cytoscape’. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.
Highlights
Transient receptor potential (TRP) channels are a superfamily of Ca2+-permeable cation channels that play a crucial role in a wide range of physiological processes [1,2]
Examples of the TRIP Database 2.0 use are illustrated in Figure 1, and the website provides instruction in the ‘Tutorial’ section
The TRIP Database 2.0 can serve as an information hub site for providing views on the molecular landscape of TRP
Summary
Transient receptor potential (TRP) channels are a superfamily of Ca2+-permeable cation channels that play a crucial role in a wide range of physiological processes [1,2]. TRP channels commonly translate various cellular stimuli into electrochemical signals, leading to changes in membrane potentials and intracellular Ca2+ levels [5]. Aberrant TRP channels have been implicated in various human diseases, such as genetic disorders, cardiovascular diseases, cancers, and neuropathic pain [6,7,8]. TRP channels have attracted much attention as promising targets for therapeutic intervention in human diseases [11]. The molecular mechanisms through which TRP channels are involved in the disease pathologies are largely unknown
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