Abstract
Three new trinor-cycloartane glycosides, 15α-hydroxy-16-dehydroxy-16(24)-en-foetidinol-3-O-β-d-xylopyranoside (1), 28-hydroxy-foetidinol-3-O-β-d-xylopyranoside (2) and foetidinol-3-O-β-d-xylopyranosyl-(1”→3’)-β-d-xylopyranoside (3) together with the known compound foetidinol-3-O-β-d-xylopyranoside (4) were isolated from the n-BuOH fraction of the roots of Cimicifuga foetida. Their structures were elucidated on the basis of spectroscopic and chemical reaction data.
Highlights
The Traditional Chinese Medicine Rhizoma Cimicifugea is used to treat toothache, mouth ulcers, sore throats and to help erupt measles [1]
Molecules 2009, 14 species in Yunnan Province [8,9,10,11], three new trinor-cycloartane glycosides 1-3 were isolated from the roots of C. foetida (Figure 1)
Since three trinor-cycloartanes were found for the first time in C. foetida between 1994 and 1996, no such type of structure have been reported in past ten years
Summary
The Traditional Chinese Medicine Rhizoma Cimicifugea is used to treat toothache, mouth ulcers, sore throats and to help erupt measles [1]. The Chinese Pharmacopoeia describes three Cimicifuga species (C. foetida, C. dahurica and C. heracleifolia) as the crude drug source [1], among which C. foetida is found widely spread throughout northwest Yunnan Province [2]. Ever since three trinor-cycloartanes were found in C. foetida by Asian research groups between. 1994-96 [3,4,5,6,7], no additional compounds with such structure have been reported, as far as we know. Molecules 2009, 14 species in Yunnan Province [8,9,10,11], three new trinor-cycloartane glycosides 1-3 were isolated from the roots of C. foetida (Figure 1)
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