Abstract
Trimethylamine N-oxide (TMAO) is an amine oxide generated in the liver from nutrients such as choline, betaine, or carnitine via an intermediate gut-bacteria driven metabolite, trimethylamine (TMA). Recently, Zhu et al . conducted a 2-month open-, non-placebo controlled intervention in vegetarians and omnivores using 450 mg total choline/day (1). Zhu et al . reported a significant increase in plasma TMAO concentrations (from 2.5 to 36.4 M in omnivores and from 2.6 to 27.2 M in vegetarians).
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