Abstract
The 28.4-kb plasmid pSK1 is found in approx. 50% of all isolates of multiresistant Staphylococcus aureus from Australian hospitals and mediates resistance to the aminoglycosides gentamicin, tobramycin and kanamycin, ethidium bromide, quaternary ammonium compounds and trimethoprim. Cloning of the trimethoprim-resistance region of pSK1 in an Escherichia coli vector/host system produced a hybrid plasmid which expressed this phenotype. Transposon mutagenesis has established that pSK1-mediated resistance to trimethoprim in S. aureus is encoded by a DNA sequence of between 0.55 and 0.75 kb.
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