Trimethoprim, a sulphonamide potentiator.

Abstract

British Journal of Pharmacology and ChemotherapyVolume 33, Issue 1 p. 72-90 Free Access TRIMETHOPRIM, A SULPHONAMIDE POTENTIATOR S. R. M. BUSHBY, S. R. M. BUSHBY Wellcome Research Laboratories, Beckenham, Kent, and Tuckahoe, New YorkSearch for more papers by this authorG. H. HITCHINGS, G. H. HITCHINGS Wellcome Research Laboratories, Beckenham, Kent, and Tuckahoe, New YorkSearch for more papers by this author S. R. M. BUSHBY, S. R. M. BUSHBY Wellcome Research Laboratories, Beckenham, Kent, and Tuckahoe, New YorkSearch for more papers by this authorG. H. HITCHINGS, G. H. HITCHINGS Wellcome Research Laboratories, Beckenham, Kent, and Tuckahoe, New YorkSearch for more papers by this author First published: May 1968 https://doi.org/10.1111/j.1476-5381.1968.tb00475.xCitations: 288AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Anton, A. H. (1960). The relation between the binding of sulfonamides to albumin and their antibacterial efficacy. J. Pharmac. exp. Ther., 129, 282– 290. Bratton, A. C., Marshall, E. K. Jr., Babbit, D. & Hendrickson, A. R. (1939). 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H. (1964). Antimetabolites and chemotherapy: Integration of biochemistry and molecular manipulation. Chemotherapy of Cancer, ed. P. A. Plattner, pp. 77– 87. Amsterdam: Elsevier Publishing Co. Hitchings, G. H. & Burchall, J. J. (1965). Inhibition of folate biosynthesis and function as a basis for chemotherapy. Advances in Enzymology, ed. F. F. Nord, vol. 27, pp. 417– 468. New York: John Wiley & Sons, Inc. Interscience Publishers Div. Hitchings, G. H., Burchall, J. J. & Ferone, R. (1966a). The comparative enzymology of dihydrofolate reductase and the design of chemotherapeutic agents. Symposia of the Society for General Microbiology. Biochemical Studies of Antimicrobial Drugs, pp. 294– 300. Hitchings, G. H., Burchall, J. J. & Ferone, R. (1966b). Comparative enzymology of dihydrofolate reductases as a basis for chemotherapy. Proceedings IIIrd International Pharmacological Congress, Sao Paulo, Brazil. Abstracts 113. Hitchings, G. H. & Bushby, S. R. M. (1961). 5-Benzyl-2,4-diaminopyrimidines, a new class of systemic antibacterial agents. 5th Int. Congress Biochem. Moscow, p. 165. Hitchings, G. H., Elion, G. B., Falco, E. A., Russell, P. B., Sherwood, M. B. & Vanderwerff, H. (1950). Antagonists of nucleic acid derivatives. I. The Lactobacillus casei model. J. biol. Chem., 183, 1– 9. Hitchings, G. H., Elion, G. B., Falco, E. A., Russell, P. B. & Vanderwerff, H. (1950). Studies on analogs of purines and pyrimidines. Ann. N.Y. Acad. Sci., 52, 1318– 1335. Hitchings, G. H., Elion, G. B. & Singer, S. (1954). Chemistry and biology of pteridines, ed. Wolstenholme, pp. 290– 303. London: Churchill. Hitchings, G. H., Elion, G. B., Vanderwerff, H. & Falco, E. A. (1948). Pyrimidine derivatives as antagonists of pteroylglutamic acid. J. biol. Chem., 174, 765– 766. Hitchings, G. H., Falco, E. A., Elion, G. B., Singer, S., Waring, G. B., Hutchison, D. J. & Burchenall, J. H. 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Soc., 80, 3449– 3457. Rollo, I. M. (1955). The mode of action of sulphonamides proguanil and pyrimethamine on Plasmodium gallinaceum. Br. J. Pharmac. Chemother., 10, 208– 214. Roth, B., Falco, E. A. & Hitchings, G. H. (1962). 5-Benzyl-2,4-diaminopyrimidines as antibacterial agents. I. Synthesis and antibacterial activity J. mednl. pharm. Chem., 5, 1103– 1123. Schneider, M., Schwarzenberg, L., Cattan, A., Schlumberger, J. R., Amiel, J. L. & Mathé, G. (1965). Essai de traitement de diverses infections a ‘Proteus’ par le 2,4 diamino 5(3,4,5 triméthoxybelzyl) pyrimidine, ou (trimethoprim). Presse med., 73, 893– 894. Sourander, L. B. & Werner, G. E. (1967). Efficacy and tolerance of sulphonamide trimethoprim combinations in geriatric patients with bactiuria. Proceedings 5th International Congress of Chemotherapy Vienna June 2. Thiersch, J. B. (1963). The effect of substituted 2,4 diaminopyrimidines on the rat fetus in utero. 3rd International Congress of Chemotherapy, International Society of Chemotherapy, Stuttgart, Germany, 367– 372. Wood, R. C., Geltzer, A. & Hitchings, G. H. (1960). Comparative effects of various antimetabolites on growth and synthesis of citrovorum factor by Streptococcus faecalis. J. Bact., 79, 306– 307. Wood, R. C. & Hitchings, G. H. (1959). A study of the uptake and degradation of folic acid, citrovorum factor, aminopterin, and pyrimethamine by bacteria. J. biol. Chem., 234, 2381– 2385. Zbinden, G. (1964). Molecular modifications in the development of newer anti-infective agents. Molecular Modifications in Drug Design, ed. R. F. Gould, p. 25. Washington, D.C.: American Chemical Society. Citing Literature Volume33, Issue1May 1968Pages 72-90 ReferencesRelatedInformation