Abstract
Trimetaquinol (TMQ), a synthetic β‐adrenoceptor stimulant (Iwasawa & Kiyomoto, 1967) has been shown to relax airway smooth muscle of guinea‐pig, cat and horse (Iwasawa & Kiyyomoto, 1967; Brittain, Jack & Ritchie, 1970): pulmonary vein of calf and horse (Hanna, Hambleton & Eyre, 1980;Hanna& Eyre, 1979) and also to benefit patients with mild to moderate asthmatic symptoms (Yamamura & Kishimoto, 1968). However, evidence has been provided which suggests that TMQ has a nonselective β‐adrenergic action and has some papaverine‐like characteristics (Brittain et al., 1970; Newman, Colella, Spainhour, Brann, Zapko‐Potapovich & Wardell, 1978). More recently, Hanna et al., 1980, using bovine pulmonary vein, reported that the venodilator effect of TMQ was neither inhibited by propranolol nor potentiated by phentolamine. These authors further emphasized the structural similarity between TMQ and papaverine. This consideration, coupled with the possibility that inhaled bronchodilators as well as endogenous sympathomimetics may alter pulmonary vascular tone and consequently pulmonary blood flow, the present investigation was undertaken to study the effects of TMQ on bovine pulmonary arteries.
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