Abstract
Trimebutine (TMB) induces migrating motor complexes (MMC) in dogs and in healthy adults. We have tested the effect of TMB on duodenal motility in children with severe digestive diseases requiring total parenteral nutrition, and with clinical features of dismotility. Five male children were studied (mean age 11.7 ± 6.8 months) : 2 protracted diarrhea, 2 intestinal pseudo-obstruction, one short bowel syndrome. Fasting duodenal motor activity was recorded by manometry during 3 hours, using a two channel probe. The basal recording exhibited in all cases a total absence of MMC and a marked hypomotility with motor indexes significantly lower than in control subjects (p < 0.02).Intravenous administration of TMB, 3 mg/kg in 1 min 30 sec raised a phase III-Like activity in 4 cases : mean delay of apparition after end of IV 88 ± 121 sec, mean duration of phase III 236 ± 105 sec, basal electrical rythm 12.75 ± 0.86 cycles/min. An aboral propagation of the activity front was observed in 2 cases. TMB administration was followed by signs of peristalsis in 2 cases.We conclude that TMB is able to induce MMC in unspecific motor disturbances, and may be very useful in improving the motor component of severe digestive diseases.
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