Abstract
Tripartite motif (TRIM) proteins play important roles in a wide range of cell physiological processes, such as signal transduction, transcriptional regulation, innate immunity, and programmed cell death. TRIM29 protein, encoded by the ATDC gene, belongs to the RING-less group of TRIM protein family members. It consists of four zinc finger motifs in a B-box domain and a coiled-coil domain, and makes use of the B-box domain as E3 ubiquitin ligase in place of the RING. TRIM29 was found to be involved in the formation of homodimers and heterodimers in relation to DNA binding; additional studies have also demonstrated its role in carcinogenesis, DNA damage signaling, and the suppression of radiosensitivity. Recently, we reported that TRIM29 interacts with keratins and FAM83H to regulate keratin distribution. Further, in cutaneous SCC, the expression of TRIM29 is silenced by DNA methylation, leading to the loss of TRIM29 and promotion of keratinocyte migration. This paper reviews the role of TRIM family proteins in malignant tumors, especially the role of TRIM29 in cutaneous SCC.
Highlights
Tripartite motif (TRIM) proteins play important roles in signal transduction, transcriptional regulation, innate immunity, programmed cell death, and other cell physiological processes [1]
The TRIM family proteins are composed of E3 ubiquitin ligase activity among the RING-finger domain
TRIM29 protein, the product of the ataxiatelangiectasia group D complementing (ATDC) gene, belongs to the RING-less group of TRIM family proteins. It consists of four zinc finger motifs in a B-box domain and a coiledcoil domain (Figure 1A), and it makes use of the B-box domain as E3 ubiquitin ligase in place of the RING [16, 17]
Summary
Received: 28 October 2021 Accepted: 02 December 2021 Published: 20 December 2021. Citation: Hsu C-Y, Yanagi T and Ujiie H (2021) TRIM29 in Cutaneous Squamous Cell. Tripartite motif (TRIM) proteins play important roles in a wide range of cell physiological processes, such as signal transduction, transcriptional regulation, innate immunity, and programmed cell death. TRIM29 protein, encoded by the ATDC gene, belongs to the RING-less group of TRIM protein family members. It consists of four zinc finger motifs in a B-box domain and a coiled-coil domain, and makes use of the B-box domain as E3 ubiquitin ligase in place of the RING. TRIM29 was found to be involved in the formation of homodimers and heterodimers in relation to DNA binding; additional studies have demonstrated its role in carcinogenesis, DNA damage signaling, and the suppression of radiosensitivity. This paper reviews the role of TRIM family proteins in malignant tumors, especially the role of TRIM29 in cutaneous SCC
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